Table 2.

Association of rs10816625, rs13294895 and rs676256 with risk of breast cancer in European and Asian women stratified by ER status, PR status and HER2 status

Locus	Population	Controls	Cases	ORa	95% CI	P-valueb	ORa	95% CI	P-valueb	Phetc
	Caucasian			ER+ tumours			ER− tumours
rs10816625		41 324	25 851 | 6128	1.14	1.09–1.19	2.39 × 10−08	1.04	0.96–1.13	0.29	0.05
rs13294895		41 323	25 851 | 6130	1.11	1.08–1.14	3.54 × 10−12	1.03	0.98–1.08	0.25	0.003
rs676256		41 324	25 847 | 6128	0.87	0.85–0.89	1.66 × 10−30	0.98	0.94–1.02	0.31	2.08 × 10−08
				PR+ tumours			PR− tumours
rs10816625		41 618	19 207 | 8470	1.16	1.10–1.22	1.36 × 10−08	1.06	0.99–1.13	0.11	0.02
rs13294895		41 617	19 207 | 8472	1.11	1.08–1.15	1.74 × 10−10	1.05	1.00–1.10	0.03	0.01
rs676256		41 619	19 207 | 8472	0.87	0.84–0.89	2.15 × 10−27	0.95	0.91–0.98	0.002	2.73 × 10−06
				HER2− tumours			HER2+ tumours
rs10816625		31 756	12 872 | 2503	1.10	1.04–1.17	0.002	1.21	1.08–1.35	9.66 × 10−04	0.09
rs13294895		31 755	12 874 | 2503	1.10	1.06–1.14	3.29 × 10−06	1.07	1.00–1.16	0.06	0.53
rs676256		31 756	12 869 | 2502	0.87	0.85–0.90	2.75 × 10−16	0.92	0.87–0.98	0.008	0.14
	Asian			ER+ tumours			ER− tumours
rs10816625		6622	3183 | 1547	1.13	1.06–1.21	1.30 × 10−04	1.14	1.05–1.24	0.002	0.84
rs13294895		6624	3183 | 1546	1.04	0.87–1.26	0.65	0.92	0.71–1.18	0.5	0.25
rs676256		6624	3184 | 1547	0.94	0.80–1.10	0.42	0.98	0.80–1.19	0.82	0.76
				PR+ tumours			PR− tumours
rs10816625		5733	2711 | 1621	1.12	1.04–1.20	0.0012	1.15	1.06–1.25	5.45 × 10−04	0.5
rs13294895		5753	2711 | 1621	1.04	0.85–1.27	0.72	0.98	0.77–1.25	0.88	0.55
rs676256		5735	2712 | 1621	1.01	0.86–1.19	0.89	0.85	0.69–1.05	0.14	0.15
				HER2– tumours			HER2+ tumours
rs10816625		3852	1058 | 785	1.17	1.05–1.30	0.0032	1.17	1.04–1.32	0.01	0.78
rs13294895		3853	1057 | 784	1.00	0.75–1.33	0.98	1.03	0.73–1.43	0.88	0.81
rs676256		3853	1058 | 785	1.00	0.80–1.26	0.98	0.87	0.66–1.16	0.34	0.27

^aStratum-specific ORs estimated using polytomous logistic regression.

^bStratum-specific P-values computed using Wald tests.

^cP-value for heterogeneity in effect estimates between strata calculated using case-only logistic regression.