Table 2.
Locus | Population | Controls | Cases | ORa | 95% CI | P-valueb | ORa | 95% CI | P-valueb | Phetc |
---|---|---|---|---|---|---|---|---|---|---|
Caucasian | ER+ tumours | ER− tumours | ||||||||
rs10816625 | 41 324 | 25 851 | 6128 | 1.14 | 1.09–1.19 | 2.39 × 10−08 | 1.04 | 0.96–1.13 | 0.29 | 0.05 | |
rs13294895 | 41 323 | 25 851 | 6130 | 1.11 | 1.08–1.14 | 3.54 × 10−12 | 1.03 | 0.98–1.08 | 0.25 | 0.003 | |
rs676256 | 41 324 | 25 847 | 6128 | 0.87 | 0.85–0.89 | 1.66 × 10−30 | 0.98 | 0.94–1.02 | 0.31 | 2.08 × 10−08 | |
PR+ tumours | PR− tumours | |||||||||
rs10816625 | 41 618 | 19 207 | 8470 | 1.16 | 1.10–1.22 | 1.36 × 10−08 | 1.06 | 0.99–1.13 | 0.11 | 0.02 | |
rs13294895 | 41 617 | 19 207 | 8472 | 1.11 | 1.08–1.15 | 1.74 × 10−10 | 1.05 | 1.00–1.10 | 0.03 | 0.01 | |
rs676256 | 41 619 | 19 207 | 8472 | 0.87 | 0.84–0.89 | 2.15 × 10−27 | 0.95 | 0.91–0.98 | 0.002 | 2.73 × 10−06 | |
HER2− tumours | HER2+ tumours | |||||||||
rs10816625 | 31 756 | 12 872 | 2503 | 1.10 | 1.04–1.17 | 0.002 | 1.21 | 1.08–1.35 | 9.66 × 10−04 | 0.09 | |
rs13294895 | 31 755 | 12 874 | 2503 | 1.10 | 1.06–1.14 | 3.29 × 10−06 | 1.07 | 1.00–1.16 | 0.06 | 0.53 | |
rs676256 | 31 756 | 12 869 | 2502 | 0.87 | 0.85–0.90 | 2.75 × 10−16 | 0.92 | 0.87–0.98 | 0.008 | 0.14 | |
Asian | ER+ tumours | ER− tumours | ||||||||
rs10816625 | 6622 | 3183 | 1547 | 1.13 | 1.06–1.21 | 1.30 × 10−04 | 1.14 | 1.05–1.24 | 0.002 | 0.84 | |
rs13294895 | 6624 | 3183 | 1546 | 1.04 | 0.87–1.26 | 0.65 | 0.92 | 0.71–1.18 | 0.5 | 0.25 | |
rs676256 | 6624 | 3184 | 1547 | 0.94 | 0.80–1.10 | 0.42 | 0.98 | 0.80–1.19 | 0.82 | 0.76 | |
PR+ tumours | PR− tumours | |||||||||
rs10816625 | 5733 | 2711 | 1621 | 1.12 | 1.04–1.20 | 0.0012 | 1.15 | 1.06–1.25 | 5.45 × 10−04 | 0.5 | |
rs13294895 | 5753 | 2711 | 1621 | 1.04 | 0.85–1.27 | 0.72 | 0.98 | 0.77–1.25 | 0.88 | 0.55 | |
rs676256 | 5735 | 2712 | 1621 | 1.01 | 0.86–1.19 | 0.89 | 0.85 | 0.69–1.05 | 0.14 | 0.15 | |
HER2– tumours | HER2+ tumours | |||||||||
rs10816625 | 3852 | 1058 | 785 | 1.17 | 1.05–1.30 | 0.0032 | 1.17 | 1.04–1.32 | 0.01 | 0.78 | |
rs13294895 | 3853 | 1057 | 784 | 1.00 | 0.75–1.33 | 0.98 | 1.03 | 0.73–1.43 | 0.88 | 0.81 | |
rs676256 | 3853 | 1058 | 785 | 1.00 | 0.80–1.26 | 0.98 | 0.87 | 0.66–1.16 | 0.34 | 0.27 |
aStratum-specific ORs estimated using polytomous logistic regression.
bStratum-specific P-values computed using Wald tests.
cP-value for heterogeneity in effect estimates between strata calculated using case-only logistic regression.