Table 3.

Association of rs10816625, rs13294895 and rs676256 with risk of breast cancer in European women stratified by combined ER/PR status

Locus	Controls	Cases	ER/PR	ORa	95% CI	P-valueb	Phetc
rs10816625	38 144	17 132	ER+/PR+	1.17	1.11–1.24	4.76 × 10−09
		3380	ER+/PR−	1.06	0.96–1.18	0.27
		714	ER−/PR+	1.12	0.90–1.38	0.30
		4436	ER−/PR−	1.07	0.98–1.18	0.12	0.03
rs13294895	38 143	17 132	ER+/PR+	1.13	1.09–1.16	6.38 × 10−08
		3380	ER+/PR−	1.07	1.01–1.15	0.03
		714	ER−/PR+	1.00	0.87–1.15	0.97
		4438	ER−/PR−	1.05	0.99–1.11	0.12	0.01
rs676256	38 144	17 128	ER+/PR+	0.87	0.84–0.89	1.33 × 10−24
		3380	ER+/PR−	0.90	0.86–0.95	1.20 × 10−04
		714	ER−/PR+	0.89	0.80–1.00	0.04
		4436	ER−/PR−	0.98	0.94–1.03	0.47	4.01 × 10−06

^aStratum-specific ORs estimated using separate logistic regression models comparing cases from each ER/PR combination with all controls.

^bStratum-specific P-values computed using Wald tests.

^cP-value from χ²-test of heterogeneity of odds ratios.