Table 4.

Association of rs10816625, rs13294895 and rs676256 with risk of ER-positive breast cancer stratified by lymph node status

Locus	Population	Controls	Cases	ORa	95% CI	P-valueb	ORa	95% CI	P-valueb	Phetc
	Caucasian			Node-negative tumours			Node-positive tumours
rs10816625		40 313	13 093 | 8235	1.19	1.12–1.25	4.55 × 10−09	1.07	0.99–1.14	0.07	5.98 × 10−03
rs13294895		40 313	13 093 | 8235	1.10	1.06–1.15	1.36 × 10−07	1.13	1.08–1.18	7.90 × 10−08	0.43
rs676256		40 313	13 090 | 8234	0.86	0.84–0.89	5.42 × 10−22	0.90	0.87–0.93	1.17 × 10−08	0.04
	Asian			Node-negative tumours			Node-positive tumours
rs10816625		4741	1084 | 740	1.13	1.02–1.25	0.02	1.11	0.98–1.24	0.03	0.77
rs13294895		4742	1083 | 740	1.16	0.88–1.53	0.29	1.07	0.78–1.49	0.66	0.72
rs676256		4742	1084 | 740	1.02	0.81–1.29	0.85	1.01	0.77–1.31	0.97	0.94

^aStratum-specific ORs estimated using polytomous logistic regression.

^bStratum-specific P-values computed using Wald tests.

^cP-value for heterogeneity in effect estimates between strata calculated using case-only logistic regression.