Table 4.
Locus | Population | Controls | Cases | ORa | 95% CI | P-valueb | ORa | 95% CI | P-valueb | Phetc |
---|---|---|---|---|---|---|---|---|---|---|
Caucasian | Node-negative tumours | Node-positive tumours | ||||||||
rs10816625 | 40 313 | 13 093 | 8235 | 1.19 | 1.12–1.25 | 4.55 × 10−09 | 1.07 | 0.99–1.14 | 0.07 | 5.98 × 10−03 | |
rs13294895 | 40 313 | 13 093 | 8235 | 1.10 | 1.06–1.15 | 1.36 × 10−07 | 1.13 | 1.08–1.18 | 7.90 × 10−08 | 0.43 | |
rs676256 | 40 313 | 13 090 | 8234 | 0.86 | 0.84–0.89 | 5.42 × 10−22 | 0.90 | 0.87–0.93 | 1.17 × 10−08 | 0.04 | |
Asian | Node-negative tumours | Node-positive tumours | ||||||||
rs10816625 | 4741 | 1084 | 740 | 1.13 | 1.02–1.25 | 0.02 | 1.11 | 0.98–1.24 | 0.03 | 0.77 | |
rs13294895 | 4742 | 1083 | 740 | 1.16 | 0.88–1.53 | 0.29 | 1.07 | 0.78–1.49 | 0.66 | 0.72 | |
rs676256 | 4742 | 1084 | 740 | 1.02 | 0.81–1.29 | 0.85 | 1.01 | 0.77–1.31 | 0.97 | 0.94 |
aStratum-specific ORs estimated using polytomous logistic regression.
bStratum-specific P-values computed using Wald tests.
cP-value for heterogeneity in effect estimates between strata calculated using case-only logistic regression.