Table 5.
Locus | Population | Controls | Cases | ORa | 95% CI | P-valueb | ORa | 95% CI | P-valueb | Phetc |
---|---|---|---|---|---|---|---|---|---|---|
Caucasian | Ductal tumours | Lobular tumours | ||||||||
rs10816625 | 34 151 | 15 007 | 3199 | 1.12 | 1.05–1.18 | 1.25 × 10−04 | 1.17 | 1.06–1.30 | 1.91 × 10−03 | 0.35 | |
rs13294895 | 34 149 | 15 007 | 3199 | 1.10 | 1.06–1.14 | 5.51 × 10−07 | 1.12 | 1.05–1.20 | 5.43 × 10−04 | 0.42 | |
rs676256 | 34 150 | 15 004 | 3199 | 0.88 | 0.85–0.90 | 1.16 × 10−18 | 0.84 | 0.80–0.89 | 5.64 × 10−10 | 0.17 | |
Asian | Ductal tumours | Lobular tumours | ||||||||
rs10816625 | 3852 | 1800 | 85 | 1.12 | 1.03–1.22 | 8.50 × 10−03 | 1.29 | 0.94–1.77 | 0.11 | 0.32 | |
rs13294895 | 3853 | 1799 | 85 | 1.16 | 0.92–1.46 | 0.22 | 1.16 | 0.47–2.87 | 0.74 | 0.96 | |
rs676256 | 3853 | 1800 | 85 | 0.91 | 0.74–1.12 | 0.38 | 1.58 | 0.84–2.96 | 0.16 | 0.13 |
aStratum-specific ORs estimated using polytomous logistic regression.
bStratum-specific P-values computed using Wald tests.
cP-value for heterogeneity in effect estimates between strata calculated using case-only logistic regression.