Table 5.

Association of rs10816625, rs13294895 and rs676256 with ER-positive breast cancer stratified by morphology

Locus	Population	Controls	Cases	ORa	95% CI	P-valueb	ORa	95% CI	P-valueb	Phetc
	Caucasian			Ductal tumours			Lobular tumours
rs10816625		34 151	15 007 | 3199	1.12	1.05–1.18	1.25 × 10−04	1.17	1.06–1.30	1.91 × 10−03	0.35
rs13294895		34 149	15 007 | 3199	1.10	1.06–1.14	5.51 × 10−07	1.12	1.05–1.20	5.43 × 10−04	0.42
rs676256		34 150	15 004 | 3199	0.88	0.85–0.90	1.16 × 10−18	0.84	0.80–0.89	5.64 × 10−10	0.17
	Asian			Ductal tumours			Lobular tumours
rs10816625		3852	1800 | 85	1.12	1.03–1.22	8.50 × 10−03	1.29	0.94–1.77	0.11	0.32
rs13294895		3853	1799 | 85	1.16	0.92–1.46	0.22	1.16	0.47–2.87	0.74	0.96
rs676256		3853	1800 | 85	0.91	0.74–1.12	0.38	1.58	0.84–2.96	0.16	0.13

^aStratum-specific ORs estimated using polytomous logistic regression.

^bStratum-specific P-values computed using Wald tests.

^cP-value for heterogeneity in effect estimates between strata calculated using case-only logistic regression.