Table 6.
Locus | Population | Controls | Casesa | Grade | ORb | 95% CI | P-valuec | Ptrendd |
---|---|---|---|---|---|---|---|---|
rs10816625 | Caucasian | 39 762 | 5233 | 1 | 1.16 | 1.07–1.26 | 4.26 × 10−04 | |
11 432 | 2 | 1.14 | 1.07–1.16 | 1.91 × 10−05 | ||||
4 655 | 3 | 1.09 | 1.00–1.19 | 0.05 | 0.26 | |||
rs13294895 | 39 763 | 5233 | 1 | 1.08 | 1.02–1.14 | 0.005 | ||
11 432 | 2 | 1.11 | 1.07–1.16 | 4.35 × 10−08 | ||||
4655 | 3 | 1.10 | 1.04–1.17 | 5.33 × 10−04 | 0.60 | |||
rs676256 | 39 763 | 5232 | 1 | 0.88 | 0.84–0.92 | 2.27 × 10−09 | ||
11 429 | 2 | 0.87 | 0.84–0.89 | 1.13 × 10−19 | ||||
4655 | 3 | 0.88 | 0.84–0.92 | 6.40 × 10−08 | 0.96 | |||
rs10816625 | Asian | 4488 | 331 | 1 | 1.02 | 0.86–1.20 | 0.85 | |
961 | 2 | 1.10 | 0.98–1.22 | 0.09 | ||||
427 | 3 | 1.42 | 1.22–1.65 | 4.88 × 10−06 | 4.91 × 10−04 | |||
rs13294895 | 4489 | 331 | 1 | 0.85 | 0.51–1.43 | 0.54 | ||
961 | 2 | 1.17 | 0.86–1.57 | 0.32 | ||||
427 | 3 | 1.25 | 0.84–1.87 | 0.27 | 0.46 | |||
rs676256 | 4489 | 331 | 1 | 1.07 | 0.75–1.53 | 0.72 | ||
961 | 2 | 1.04 | 0.81–1.33 | 0.75 | ||||
427 | 3 | 0.68 | 0.46–1.02 | 0.06 | 0.06 |
aMaximum total number of cases for each stratum.
bStratum-specific ORs estimated using polytomous logistic regression.
cStratum-specific P-values computed using Wald tests.
dP-value for linear trend in effect estimates across strata calculated using case-only logistic regression.