Table 6.

Association of rs10816625, rs13294895 and rs676256 with ER-positive breast cancer stratified by tumour grade

Locus	Population	Controls	Casesa	Grade	ORb	95% CI	P-valuec	Ptrendd
rs10816625	Caucasian	39 762	5233	1	1.16	1.07–1.26	4.26 × 10−04
			11 432	2	1.14	1.07–1.16	1.91 × 10−05
			4 655	3	1.09	1.00–1.19	0.05	0.26
rs13294895		39 763	5233	1	1.08	1.02–1.14	0.005
			11 432	2	1.11	1.07–1.16	4.35 × 10−08
			4655	3	1.10	1.04–1.17	5.33 × 10−04	0.60
rs676256		39 763	5232	1	0.88	0.84–0.92	2.27 × 10−09
			11 429	2	0.87	0.84–0.89	1.13 × 10−19
			4655	3	0.88	0.84–0.92	6.40 × 10−08	0.96
rs10816625	Asian	4488	331	1	1.02	0.86–1.20	0.85
			961	2	1.10	0.98–1.22	0.09
			427	3	1.42	1.22–1.65	4.88 × 10−06	4.91 × 10−04
rs13294895		4489	331	1	0.85	0.51–1.43	0.54
			961	2	1.17	0.86–1.57	0.32
			427	3	1.25	0.84–1.87	0.27	0.46
rs676256		4489	331	1	1.07	0.75–1.53	0.72
			961	2	1.04	0.81–1.33	0.75
			427	3	0.68	0.46–1.02	0.06	0.06

^aMaximum total number of cases for each stratum.

^bStratum-specific ORs estimated using polytomous logistic regression.

^cStratum-specific P-values computed using Wald tests.

^dP-value for linear trend in effect estimates across strata calculated using case-only logistic regression.