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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Medchemcomm. 2014 Nov 28;6(3):444–454. doi: 10.1039/C4MD00412D

Figure 2. General formula of target compounds and their pharmacophoric features.

Figure 2

R1 contains a hydrogen bond forming atom and/or a positively charged center. Various R2 and R3 substituents are incorporated on the two phenyl rings to meet the pharmacophoric requirements.