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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Medchemcomm. 2014 Nov 28;6(3):444–454. doi: 10.1039/C4MD00412D

Scheme 1.

Scheme 1

Reagents and conditions: a. morpholine or N-methyl piperazine, CuI, L-proline, K2CO3, DMSO, N2, 100–110°C; b. Pd/C, H2, CH3OH or THF; c. the appropriate amine, Et3N, EtOH; d. CF3COOH, i-PrOH or 2-BuOH, reflux; e. 3-Nitroaniline (for 7) or 3-aminobenzoic acid (for 10), CF3COOH, i-PrOH or 2-BuOH, reflux; f. the appropriate acid or amine, DIEA, HATU, DMF.