Table 4.
Inhibitory activities of selected compounds against CDK2/cyclin E1 and CDK9/cyclin T1
| Compd. | IC50 (μM)*
|
|
|---|---|---|
| CDK2/CyclinE1 | CDK9/CyclinT1 | |
| 6d | 5.85 | 0.33 |
| 6f | > 10 # | > 10 |
| 9d | 15.30 | 2.57 |
| 9f | 1.24 | 2.45 |
| 9g | 1.71 | 0.78 |
| 9h | 3.27 | 2.02 |
| 11b | 22.10 | 11.30 |
| 11e | 60.60 | 15.60 |
| 11f | 4.65 | 1.72 |
| FVP | 0.13 | 4.59 (nM) |
*
The IC50 value was interpolated from dose-response data with at least six different concentrations. Each test was performed in duplicate. Data represent the average of duplicate measurements.
#
No significant inhibition was observed at the concentration of 10 μM.