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. 2014 Sep 3;14:63. doi: 10.1186/1475-2867-14-63

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© Teng et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Combined treatment with ribavirin and IFN-α affected the RCC cell cycle. (A) Combination of 500 IU/ml of IFN-α and 500 μM ribavirin blocked the G2/M phase cell cycle transition of 786–0 cells, in comparison with untreated control 786–0 cells. The percentage of 786–0 cells in the G0/G1 phase increased significantly to 58.32% but the percentage of cells in the G2/M phase decreased to 13.95%. (B) Quantitative analysis of the cell cycle distribution of 786–0 cells treated with ribavirin alone, IFN-α alone, or a combination of ribavirin and IFN-α (* < 0.05 versus control group).