Table 1.
The characteristic data of 66 patients in DOC
| Pats. | Diag. | Sex/age, y | Cause | Lesions (CT or MRI) | Mon. after insult | Left auditory cortex(mm 3 ) | Right auditory cortex(mm 3 ) | 3 mon. diagnosis | 6 mon. diagnosis | 12 mon. diagnosis | Activation type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| VS1 | VS | M/47 | TBI | Brain stem lesions | 8 | 0 | 0 | VS | VS | VS | No |
| VS2 | VS | F/55 | CVA | Right temporal lobe lesions | 26 | 14,025 (165) | 13,005 (153) | VS | VS | VS | High |
| VS3 | VS | M/20 | TBI | Left temporal lobe lesions | 20 | 0 | 10,115 (119) | VS | VS | MCS | High |
| VS4 | VS | M/3Y.2 M | Anoxic brain injury | Diffuse brain contusion | 4 | 1,700 (20) | 0 | VS | VS | VS | Primary |
| VS5 | VS | M/64 | TBI | Bilateral frontal and left temporal lobe lesions | 8 | 8,245 (97) | 0 | VS | MCS | MCS | High |
| VS6 | VS | M/59 | TBI | Bilateral fontal, left parietal, and temporal lobe lesions | 1 | 0 | 15,725 (185) | EMCS | MCS | MCS | High |
| VS7 | VS | M/73 | CVA | Right cerebellum lesions | 2 | 2,210 (26) | 3,485 (41) | MCS | VS | VS | Primary |
| VS8 | VS | F/3 | Meningitis | — | 5 | 0 | 4,250 (50) | VS | VS | Died | Primary |
| VS9 | VS | M/47 | Anoxic brain injury | — | 2 | 2,125 (25) | 0 | MCS | EMCS | EMCS | Primary |
| VS10 | VS | F/69 | TBI | Bilateral frontal, parietal lobe, and left temporal lobe lesions | 4 | 15,130 (178) | 0 | VS | VS | VS | High |
| VS11 | VS | M/20 | TBI | Diffuse brain lesion | 24 | 12,325 (145) | 0 | MCS | MCS | MCS | High |
| VS12 | VS | M/31 | TBI | Brain stem, right temporal lobe, and left frontal lobe lesions | 6 | 0 | 1,275 (15) | MCS | MCS | MCS | Primary |
| VS13 | VS | M/48 | TBI | Right frontal, temporal, parietal, and left frontal lobe lesions | 2 | 30,515 (150) | 6,375 (75) | MCS | Died | Died | High |
| VS14 | VS | M/54 | CVA | Right frontal and temporal lobe lesions | 2 | 0 | 1,360 (16) | VS | VS | Died | Primary |
| VS15 | VS | M/27 | TBI | Diffuse brain contusion, subarachnoid hemorrhage | 1 | 0 | 0 | EMCS | EMCS | EMCS | No |
| VS16 | VS | M/28 | TBI | Diffuse brain hemorrhage | 60 | 0 | 0 | MCS | MCS | — | No |
| VS17 | VS | M/17 | Anoxic brain injury | Diffuse cortical atrophy | 6 | 0 | 5,355 (63) | VS | VS | VS | High |
| VS18 | VS | F/31 | TBI | Right frontal and temporal lobe lesions | 2 | 24,650 (290) | 9,265 (109) | MCS | MCS | MCS | High |
| VS19 | VS | F/8 | TBI | Subdural fluid accumulation, cerebromalacia in right basal ganglia | 3 | 0 | 23,630 (278) | MCS | MCS | MCS | High |
| VS20 | VS | M/36 | Anoxic brain injury | Diffuse brain contusion | 2 | 0 | 2,550 (30) | VS | VS | VS | Primary |
| VS21 | VS | M/24 | Anoxic brain injury | Subarachnoid hemorrhage, diffuse brain contusion | 2 | 1,360 (16) | 2,380 (28) | VS | — | — | Primary |
| VS22 | VS | M/60 | TBI | Left parietal lobe hemorrhage | 3 | 20,995 (247) | 0 | MCS | MCS | MCS | High |
| VS23 | VS | M/19monh | TBI | Extensive brain lesions | 2 | 9,010 (106) | 40,885 (481) | MCS | MCS | MCS | High |
| VS24 | VS | M/29 | Anoxic brain injury | Diffuse cortical atrophy | 48 | 1,360 (16) | 0 | VS | VS | VS | Primary |
| VS25 | VS | M/42 | TBI | Diffuse brain lesions | 2 | 0 | 1,275 (15) | VS | VS | — | Primary |
| VS26 | VS | F/52 | TBI | Right frontal and left temporal lobe lesions | 2 | 0 | 765 (9) | VS | VS | — | Primary |
| VS27 | VS | M/38 | TBI | Left occipital lobe and bilateral basal ganglia lesions | 4 | 20,995 (247) | 8,330 (98) | MCS | MCS | — | High |
| VS28 | VS | M/21 | TBI | Right temporal, frontal, and parietal lobe lesions | 4 | 15,385 (180) | 4,505 (53) | MCS | MCS | — | High |
| VS29 | VS | M/58 | Anoxic brain injury | Temporal and parietal lobe lesions | 4 | 0 | 0 | VS | VS | — | No |
| VS30 | VS | M/61 | TBI | Left temporal and frontal lobe lesions | 8 | 0 | 0 | VS | VS | Died | No |
| VS31 | VS | M/63 | TBI | Frontal and right temporal lobe contusion | 18 | 0 | 2,530 (22) | VS | MCS | MCS | Primary |
| VS32 | VS | F/45 | TBI | Left subdural hematoma and extensive brain contusion | 3 | 3,105 (27) | 4,370 (38) | MCS | MCS | MCS | High |
| VS33 | VS | M/45 | TBI | Left epidural hematoma | 12 | 3,450 (30) | 0 | VS | VS | VS | Primary |
| VS34 | VS | M/23 | Anoxic brain injury | Diffuse cortical atrophy | 17 | 0 | 2,645 (23) | VS | VS | VS | Primary |
| VS35 | VS | M/20 | Anoxic brain injury | Diffuse cortical atrophy | 7 | 0 | 0 | VS | VS | VS | No |
| VS36 | VS | M/43 | CVA | Bilateral basal ganglia hemorrhage | 3 | 19,090 (166) | 8,970 (78) | VS | VS | VS | High |
| VS37 | VS | M/21 | TBI | Diffuse axonal injury, subarachnoid hemorrhage | 6 | 3,680 (32) | 0 | VS | VS | VS | Primary |
| VS38 | VS | F/38 | Anoxic brain injury | Lateral ventricle expansion | 3 | 0 | 0 | VS | VS | VS | No |
| VS39 | VS | M/54 | Anoxic brain injury | Diffuse cortical atrophy | 2 | 0 | 2,760 (24) | VS | VS | — | Primary |
| MCS1 | MCS | F/46 | TBI | Left temporal lobe lesions | 3 | 0 | 11,645 (137) | MCS | EMCS | EMCS | High |
| MCS2 | MCS | M/42 | TBI | Bilateral frontal and left temporal lobe lesions | 5 | 4,165 (49) | 0 | MCS | EMCS | EMCS | High |
| MCS3 | MCS | M/45 | TBI | Diffuse brain lesions | 7 | 50,830 (598) | 27,880 (328) | MCS | MCS | — | High |
| MCS4 | MCS | M/46 | TBI | Right frontal, temporal, and parietal lobe hematoma | 4 | 12,580 (148) | 5,100 (60) | VS | VS | VS | High |
| MCS5 | MCS | M/33 | TBI | Bilateral frontal and left parietal lobe lesions | 1 | 12,750 (150) | 0 | EMCS | EMCS | EMCS | High |
| MCS6 | MCS | F/29 | TBI | Left frontal and parietal lobe hematoma | 2 | 1,020 (12) | 0 | EMCS | EMCS | EMCS | Primary |
| MCS7 | MCS | M/21 | TBI | Left temporal hematoma and right subdural hematoma | 3 | 9,095 (107) | 28,390 (334) | MCS | MCS | Died | High |
| MCS8 | MCS | M/65 | TBI | Bilateral frontal lobe lesions, subarachnoid hemorrhage | 3 | 0 | 19,550 (230) | EMCS | EMCS | EMCS | High |
| MCS9 | MCS | M/20 | TBI | Subarachnoid hemorrhage | 3 | 23,120 (272) | 12,240 (144) | MCS | MCS | MCS | High |
| MCS10 | MCS | M/19 | TBI | Diffuse axonal contusion | 1 | 3,655 (43) | 4,845 (57) | EMCS | EMCS | EMCS | High |
| MCS11 | MCS | M/60 | TBI | Left frontal and temporal hematoma | 2 | 0 | 10,710 (126) | MCS | MCS | — | High |
| MCS12 | MCS | M/32 | TBI | Right frontal, bilateral temporal and parietal lobe lesions | 2 | 935 (11) | 1,445 (17) | EMCS | EMCS | EMCS | Primary |
| MCS13 | MCS | F/64 | CVA | Subarachnoid hemorrhage | 8 | 7,140 (84) | 0 | EMCS | EMCS | EMCS | High |
| MCS14 | MCS | M/30 | TBI | Right temporal and frontal lobe lesions | 2 | 23,120 (272) | 16,405 (193) | MCS | EMCS | — | High |
| MCS15 | MCS | F/24 | TBI | Subdural hematoma, brainstem lesions | 3 | 25,160 (296) | 15,470 (179) | MCS | EMCS | — | High |
| MCS16 | MCS | M/38 | TBI | Bilateral temporal and frontal lobe lesions | 6 | 0 | 22,780 (268) | MCS | MCS | — | High |
| MCS17 | MCS | M/30 | TBI | Left temporal and bilateral frontal lobe lesions | 26 | 0 | 18,275 (215) | MCS | MCS | — | High |
| MCS18 | MCS | M/50 | CVA | Left basal ganglia and brain stem hemorrhage | 14 | 0 | 805 (7) | MCS | MCS | MCS | Primary |
| MCS19 | MCS | F/56 | CVA | Brian stem hemorrhage | 24 | 0 | 3,335 (29) | MCS | MCS | MCS | High |
| MCS20 | MCS | F/59 | CVA | Left basal ganglia and paraventricle hemorrhage | 5 | 0 | 3,995 (47) | MCS | MCS | MCS | High |
| MCS21 | MCS | M/62 | CVA | Left cerebellum hemorrhage | 17 | 1,035 (9) | 0 | MCS | MCS | MCS | Primary |
| MCS22 | MCS | M/37 | TBI | Bilateral frontal and left basal ganglia hemorrhage | 4 | 0 | 2,760 (24) | EMCS | EMCS | EMCS | Primary |
| MCS23 | MCS | M/42 | TBI | Bilateral frontal and temporal contusion and hemorrhage | 24 | 7,990 (94) | 0 | EMCS | EMCS | EMCS | High |
| MCS24 | MCS | M/50 | TBI | Brain stem, left temporal, right frontal and bilateral occipital contusion | 9 | 8,925 (105) | 0 | MCS | MCS | MCS | High |
| MCS25 | MCS | M/23 | Anoxic brain injury | Diffuse axonal atrophy | 28 | 0 | 11,845 (103) | MCS | MCS | MCS | High |
| EMCS1 | EMCS | M/32 | CVA | Bilateral basal ganglia, brain stem, and right cerebellum lesions | 13 | 0 | 3,740 (44) | EMCS | EMCS | EMCS | Primary |
| EMCS2 | EMCS | M/58 | TBI | Left subdural hematoma | 2 | 11,560 (136) | 9,690 (114) | EMCS | EMCS | EMCS | High |
Show the characteristic data, activation volume (mm3) and voxel number (in brackets) of right and left side of auditory cortex, the follow-up diagnosis at 3, 6, and 12 months, and the activation type (Low, No, Lower level; High, higher level) of the patients with disorders of consciousness. TBI, Traumatic brain injury; CVA, Cerebrovascular accident; MCS, Minimally conscious state; EMCS, Emergence from minimally conscious state; VS, Vegetative state. Consent for the publication of the information relating to individual participants was obtained from the legal representative of all participants.