Figure 1.

Model for dual TCR reactivity. Three possible mechanisms exist for dual reactivity of the TCR in autoimmune disease: (1) molecular mimicry, where one TCR recognizes virus and self; (2) dual TCRs, where one TCR is specific for virus and the other TCR is specific for self; and (3) a chimeric TCR, where different Vα and Vβ combinations on a single T cell are responsible for recognizing both virus and self. Source: Previously published as Fig. 8 in Ref. [54▪].