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. Author manuscript; available in PMC: 2015 Apr 22.

Published in final edited form as: Int J Hematol. 2014 Feb 2;99(3):272–278. doi: 10.1007/s12185-014-1503-4

Table 2.

Toxicity Profile

		Grade 1/2	Grade 3/4	Grade 5
Cardiovascular	Cohort 1	1
Cardiovascular	Cohort 2	2

Skin	Cohort 1
Skin	Cohort 2	2

Gastrointestinal	Cohort 1	1
Gastrointestinal	Cohort 2	4

Hematological	Cohort 1	4	5
Hematological	Cohort 2	16	24

Hepatic	Cohort 1	7
Hepatic	Cohort 2	19

Infections	Cohort 1		1
Infections	Cohort 2	2	5

Metabolic	Cohort 1	14	3
Metabolic	Cohort 2	29	5

Neurological	Cohort 1	1
Neurological	Cohort 2

Pulmonary	Cohort 1	3		1
Pulmonary	Cohort 2	5	2

Genito-urinary	Cohort 1
Genito-urinary	Cohort 2	1

Others	Cohort 1
Others	Cohort 2	3	1

Number of different grade toxicities observed in each organ system is shown under each column