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. Author manuscript; available in PMC: 2015 Apr 22.
Published in final edited form as: Eur J Med Chem. 2014 Sep 8;86:769–781. doi: 10.1016/j.ejmech.2014.09.019

Scheme 3.

Scheme 3

Synthesis of 2-chloropurine derivatives 6a and 6b. Reagents and conditions: (i) EtC(OEt)3,1 h, MW 160 °C; (ii) t-BuNH2, NMP, 2 h, MW 160 °C; (iii) 3,4-DHP, PTSA cat., EtOAc, 6 h, 60 °C