. Author manuscript; available in PMC: 2015 Apr 22.

Published in final edited form as: Eur J Med Chem. 2014 Sep 8;86:769–781. doi: 10.1016/j.ejmech.2014.09.019

Table 2.

Topo-IIα inhibition activity and antiproliferative activity (GI50/µM) of the fluorinated purine derivatives and QAP1.

Compound	Topo-IIα inhibition/ 100 µM	SK-BR-3 cells		MCF-7 cells
Compound	Topo-IIα inhibition/ 100 µM	GI₅₀/µM	R²	GI₅₀/µM	R²
18	+	6.8 ± 0.8	0.975	14.5 ± 0.5	0.903
19b	+	8.0 ± 0.8	0.936	46.3 ± 0.9	0.958
20	+	13.6 + 0.9	0.954	4.9 ± 0.3	0.966
21b	−	>100	N/A^a	>100	N/A
22b	+	2.0 + 0.9	0.988	13.6 ± 0.7	0.954
23b	+	7.0 ± 0.9	0.981	3.2 ± 0.7	0.966
24b	−	>100	N/A	>100	N/A
25b	+	11.4 + 0.8	0.965	>100	N/A
QAP1	+	10.2 ± 0.9	0.977	32 ± 2	0.961

Not applicable.