Table 2. Comparison of Good and Mild responders.

Variables	Good responders	Mild responders	p-value
Age (years)	51.6 ± 11.2	46.8 ± 8.9	n.s.
Duration of illness (years)	16.6 ± 5.7	13.5 ± 9.7	n.s.
Global Impression of change (pts)	2.7 ± 0.5	1.8 ± 0.6	< 0.0005
Duration of B12 injections (years)	8.1 ± 6.4	2.2 ± 2.3	< 0.0005
Interval days between B12 inj.	3.8 ± 1.9	5.8 ± 1.7	< 0.03
Folic acid mg/day	6.7 ± 6.6	1.9 ± 2.0	< 0.003
Use of high-concentrated B12	14/15 = 93%	13/23 = 57%	< 0.03
MTHFR compound heterozygote	1/15 = 7%	8/23 = 35%	n.s. (< 0.07)
Daily use of Thyroid hormone	7/15 = 47%	2/23 = 9%	< 0.02
Daily use of prescribed analgesic	0/15 = 0%	16/23 = 70%	< 0.0005
Fibromyalgia as part of ME	3/15 = 20%	12/23 = 52%	n.s. (< 0.09)

Mean ± SD or frequency/percentage for a number of variables in Good (n = 15) or Mild responders (n = 23). P-value is calculated by Student’s t-test, or by Fischer’s exact two-tailed test in the categorical data. (n.s. = no significance)