Table 4.

OR Estimates for Stroke in Bivariate Logistic Regression Models According to Quartiles of FEI in Postmenopausal Women in a Prospective Case-Control Study of Incident Stroke From the Study of Osteoporotic Fractures^a

	OR Estimate (95% CI)
Covariate	Quartile 1	Quartile 2	Quartile 3	Quartile 4 (Highest)
Age only	1 [Reference]	1.46 (0.80–2.68)	1.52 (0.83–2.78)	2.31 (1.28–4.17)
Age + hypertension	1 [Reference]	1.36 (0.73–2.53)	1.51 (0.81–2.79)	2.04 (1.12–3.73)
Age + current smoking	1 [Reference]	1.43 (0.78–2.63)	1.47 (0.80–2.69)	2.29 (1.27–4.13)
Age + alcohol intake	1 [Reference]	1.44 (0.79–2.64)	1.51 (0.83–2.77)	2.28 (1.26–4.11)
Age + weight	1 [Reference]	1.48 (0.81–2.72)	1.56 (0.84–2.90)	2.41 (1.26–4.59)
Age + BMI	1 [Reference]	1.47 (0.80–2.70)	1.53 (0.82–2.86)	2.34 (1.22–4.49)
Age + waist circumference	1 [Reference]	1.39 (0.76–2.57)	1.36 (0.73–2.55)	1.90 (0.99–3.66)
Age + TG level	1 [Reference]	1.46 (0.79–2.70)	1.41 (0.76–2.63)	1.79 (0.95–3.39)
Age + TC:HDL-C ratio	1 [Reference]	1.39 (0.75–2.58)	1.33 (0.71–2.49)	1.81 (0.96–3.40)
Age + HDL-C level	1 [Reference]	1.46 (0.79–2.69)	1.43 (0.76–2.67)	2.06 (1.10–3.85)
Age + LDL-C level	1 [Reference]	1.48 (0.80–2.74)	1.53 (0.83–2.82)	2.06 (1.13–3.77)
Age + TC level	1 [Reference]	1.49 (0.81–2.75)	1.52 (0.82–2.80)	2.24 (1.23–4.08)
Age + diabetes mellitus	1 [Reference]	1.34 (0.72–2.47)	1.40 (0.76–2.59)	1.91 (1.05–3.50)
Age + CRP level	1 [Reference]	1.34 (0.73–2.48)	1.37 (0.75–2.53)	1.94 (1.05–3.59)

Abbreviations: BMI, body mass index; CI, confidence interval; CRP, C-reactive protein; FEI, free estradiol index; HDL-C, high-density lipoprotein level; LDL-C, low-density lipoprotein cholesterol; OR, odds ratio; TC, total cholesterol; TG, triglyceride.

^aThe FEI was calculated by dividing total estradiol level (in picomoles per liter) by SHBG level (in nanomoles per liter) (to convert estradiol to picomoles per liter, multiply by 3.671; SHBG to nanomoles per liter, multiply by 8.896).