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. Author manuscript; available in PMC: 2016 Jun 28.
Published in final edited form as: Cancer Lett. 2015 Mar 28;362(1):70–82. doi: 10.1016/j.canlet.2015.03.037

Fig. 5. Regulation of FBXO11 by EMT-inducing signals and expression of FBXO11 in human cancer.

Fig. 5

(A) To induce EMT, A549 cells were treated with TGFβ or nickel for 2 days, and DLD1 cells stably expressing inducible Snai1 (Sna-ER) were exposed to 4-hydroxytamoxifen (4HT) for 2 days. Cells were subsequently subjected to RT-qPCR analysis for FBXO11 and E-cadherin.

(B) Expression of FBXO11 correlates with indicated epithelial markers and inversely with mesenchymal markers in a lung cancer cohort (n = 286). Clustering was based on expression levels of EMT markers. Green indicates lower expression, and red indicates higher expression.

(C) FBXO11 is a robust predictor for favorable clinical outcome in cancer. Kaplan-Meier 10-yr overall survival was based on expression levels of E-cadherin or FBXO11 in a large cohort of lung cancer patients (n = 1405). The online survival analysis software was previously reported [36].