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. Author manuscript; available in PMC: 2015 Apr 22.
Published in final edited form as: J Neurogenet. 2014 Apr 22;28(0):98–111. doi: 10.3109/01677063.2014.892486

Figure 6.

Figure 6

Enhanced SKF81297 modulation of synaptic NMDAR currents in PSD-95-ΔGK mice. (a) Representative NMDA-EPSCs recorded from WT and mutant PFC pyramidal neurons before and (30-40 min) after bath application of SKF81297 (1 μM). (b) Summary of SKF81297 effect on NMDA-EPSCs in WT and PSD-95-/- mice. NMDA-EPSCs were pharmacologically isolated in Mg2+-free ACSF containing CNQX (20 μM), glycine (1 μM), and picrotoxin (100 μM). Neurons were voltage clamped at −60 mV. Following a 10-min baseline recording, a brief (5-10 min) application of SKF81297 elicited a long-lasting potentiation of NMDA-EPSCs in WT neurons, which was further enhanced in PSD-95-ΔGK neurons. Numbers in parentheses indicate numbers of cells analyzed.