Table 1.

General features of wild-type and Ctsk^−/− mice from young (6-month-old) and old (24-month-old) groups

Parameters	WT-young	WT-old	Ctsk−/−-young	Ctsk−/−-old
Body weight (g)	23.55 ± 0.68	27.1 ± 1.27*	24.39 ± 0.79	25.96 ± 0.57
Heart weight (g)	0.125 ± 0.007	0.182 ± 0.006*	0.134 ± 0.008	0.158 ± 0.006†,‡
Liver weight (g)	1.359 ± 0.051	1.602 ± 0.037*	1.557 ± 0.084	1.409 ± 0.080
Kidney weight (g)	0.279 ± 0.011	0.438 ± 0.020*	0.381 ± 0.026	0.423 ± 0.027
Spleen weight (g)	0.088 ± 0.006	0.11 ± 0.009*	0.099 ± 0.005	0.096 ± 0.015
HW/BW (mg g−1)	5.440 ± 0.146	6.741 ± 0.302*	5.512 ± 0.292	6.093 ± 0.211
LW/BW (mg g−1)	59.211 ± 0.656	59.378 ± 0.347	63.996 ± 3.340	54.646 ± 3.619

Values are mean ± SEM, n = 6–10 mice per group.

^*P < 0.05 vs. WT-Young group.

^†P < 0.05 vs. Ctsk^−/−-Young group.

^‡P < 0.05 vs. WT-Old group.