Table 1.
Mutations observed in young and old WT clones following pedigree analysis
| WT | ||||||||
|---|---|---|---|---|---|---|---|---|
| Y1 | Y2 | Y3 | Y4 | O1 | O2 | O3 | O4 | |
| Substitutions Position | ||||||||
| Noncoding | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 |
| Nonsense | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Missense | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Silent | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Indels Position | ||||||||
| Noncoding | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 2 |
| Coding | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| All Mutations | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 3 |
| Mean (×10−10) | 2.65 × 10−10 | 4.1 × 10−10 | ||||||
Mutation distributions for each pedigree lines are shown after completion of six cycles of aging. Mean mutation rates are calculated based on the total number of substitutions and small indels divided by the total number of generations for four lines. The whole list of mutations together with positions and nucleotide changes is shown in Table S1. Y is young, and O is old.