Fig 4.

Low λ5 increases survival in pro-B cells challenged with either TNFα or TGFβ. Unfractionated bone marrow cells (1 × 10⁶ ml⁻¹) from wild-type (WT), λ5 heterozygous deficient, or λ5-homozygous-deficient 2- to 3-month-old B6 mice were cultured with either 10 ng ml⁻¹ rmTNFα or 10 ng ml⁻¹ rmTGFβ in IL-7 CFU assays. Colonies were counted at 8 days. Normalized IL-7 CFU values were obtained in 6–12 individual experiments. Statistical significance (two-tailed Student's t-test): ****, P < 0.0001.