Table 1.
Overview of the DNA methylation data sets
| Tissue source | Platform | N (total) | Perc. female, % | N (DS) | Mean Age (range) | GEO ID | Citation | P-value |
|---|---|---|---|---|---|---|---|---|
| 1. Leukocytes | 27K | 56 | 70 | 35 | 43 (22, 64) | GSE25395 | Kerkel et al. (2010) | 0.0048 |
| 2. Brain | 450K | 71 | 47 | 15 | 53 (32, 64) | GSE63347 | Current article | 5.5E-7 |
| 3. Whole blood | 27K | 87 | 63 | 29 | 33 (9,83) | GSE52588 | Current article | 0.00056 |
| 4. Buccal epithelium | 27K | 20 | 50 | 10 | 34 (27, 47) | GSE50586 | Jones et al. (2013b) | 0.26 |
The rows correspond to the data sets used in this article. Columns report the tissue source, DNAm platform, total number of samples (N), percent female, number of DS samples, mean age (and range, i.e., minimum age, maximum age), data access information, and citation. The last column reports a (Kruskal–Wallis test) P-value regarding the relationship between age acceleration and DS status. Additional details can be found in the Supporting Information.