Table 1. Summary of KIRREL3 interacting proteins.

Interacting region	Protein ID	Description	Gene location	MIM	Function
KIRREL3-ECD	MAP1BLC1	Microtubule-associated protein 1B light chain 1	5q13	157129	Involved in the development of actin-based membrane cytoskeleton
	MYO16	Myosin XVI	13q33.3	615479	Indirectly affects actin cytoskeleton through its interaction with WAVE1 complex
KIRREL3-ICD	CASK	Calcium/calmodulin-dependent serine protein kinase (MAGUK family)	Xp11.4	300172	Localizes to synaptic active zones and binds to—neurexin and calcium channels
	ATP1B1	ATPase, Na+/K+ transporting, beta 1 polypeptide	1q24	182330	Involved in cell adhesion and establishing epithelial cell polarity
	SHMT2	Serine hydroxymethyltransferase 2 (mitochondrial)	12q12-q14	138450	Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA
	UFC1	Ubiquitin-fold modifier conjugating enzyme 1	1q23.2	610554	E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.