Table 2. Major genetic changes in HCC samples.

	HBV transcripts positive																																												HBV negative
	HBV-MLL4+								HBV-MLL4 negative
Sample	315T	316T	348T	351T	358T	320T	328T	353T	322T	363T	362T	332T	317T	329T	307T	312T	330T	323T	360T	335T	346T	354T	361T	334T	345T	304T	342T	350T	310T	352T	311T	349T	355T	314T	325T	305T	319T	339T	326T	327T	347T	321T	333T	309T	308T	337T	336T	356T	359T	357T
HBV-MLL4	◆	◆	◆	◇	◇	◇	◇	◇
TP53	×	*							*	*	*	*	*	×	×	×	×	×	×	×	×	×	×	×								×													×	×
CTNNB1							*													*					*	*	*	*	*																		*	*
c-Met																				○										○

^◆ HBV-MLL4 integration in exon;

^◇ HBV-MLL4 integration in intron;

* hotspot mutations, including TP53 R249S and CTNNB1 mutations;

^× TP53 non-hotspot mutations;

^○ c-Met gene amplificat