Table 2.
Plasmablastic lymphoma
PBL of the oral mucosa type | PBL with plasmacytic differentiation | |
---|---|---|
Histology | May have minimal plasmacytic differentiation | Plasmacytic differentiation marked |
Clinical associations | Usually associated with HIV | May be associated with transplants, autoimmune disease, advanced age, rarely occurs in immunocompetent individuals |
Site | Usually extranodal Often involves the oral cavity, nasal and paranasal sinuses |
May involve lymph nodes Uncommon in the oral cavity |
EBV-EBER | EBV positive in almost all cases | EBV positive in 60–75% of the cases |
Abbreviations: DLBCL, diffuse large B-cell lymphoma; EBV, Epstein-Barr virus; PBL, plasmablastic lymphoma.