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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Circ Cardiovasc Genet. 2014 Dec 31;8(2):389–397. doi: 10.1161/CIRCGENETICS.114.000597

Figure 1.

Figure 1

Manhattan plot displaying the association of approximately 2.5 million SNPs with circulating concentrations of hepatocyte growth factor (HGF), angiopoietin-2 (Ang-2) and soluble Tie-2 (sTie-2) in the Framingham Heart Study sample. Each dot represents a single nucleotide polymorphism. On the x-axis, the chromosomal location of the genetic variant is shown (with the results being plotted from the p terminal end). On the y-axis, the −log10 (p-value) is shown. The grey horizontal line indicates the threshold of genome-wide significance (5 × 10−8).