Table 1.
Clinical and biochemical characteristics of the discovery and replication samples
| Discovery sample (FHS 3rd Generation) | Replication sample (SHIP-1)* | |||
|---|---|---|---|---|
| Variables | Women (n=1904) | Men (n=1670) | Women (n=1654) | Men (n=1546) |
| Clinical features | ||||
| Age, yrs. | 40±9 | 40±9 | 53±15 | 55±15 |
| Systolic blood pressure, mm Hg | 113±14 | 121±12 | 128±19 | 137±19 |
| Diastolic blood pressure, mm Hg | 73±9 | 78±9 | 79±10 | 83±11 |
| Body mass index, kg/m2 | 26±6 | 28±5 | 27±6 | 28±4 |
| Waist circumference, inches | 35±6 | 39±5 | 34±2 | 39±5 |
| Smoking, % | 15 | 16 | 19 | 25 |
| Diabetes, % | 2 | 3 | 9 | 12 |
| Biochemical features | ||||
| Total cholesterol, mg/dL | 185±34 | 193±37 | 217±45 | 211±45 |
| HDL cholesterol, mg/dL | 61±16 | 47±12 | 51±17 | 39±13 |
| Triglycerides, mg/dL | 97±63 | 134±106 | 138±119 | 186±176 |
| Alcohol consumption† | 5.8±7.9 | 13.8±18.1 | 4.4±6.5 | 14.6±21.1 |
| eGFR, ml/min/1.73m2 | 99±19 | 100±17 | 111±28 | 86±22 |
| Endothelial growth factors | ||||
| HGF, Pg/mL | 825 (697, 974) | 814 (702, 967) | Not determined | Not determined |
| Angiopoietin-2, ng/mL | 2.02 (1.51,2.71) | 1.70 (1.33,2.23) | 1.37 (1.06, 1.84) | 1.30 (1.02, 1.75) |
| Soluble Tie-2, ng/mL | 14.3 (12.0,17.3) | 15.0 (12.7,18.2) | 15.0 (12.3, 17.9) | 16.1 (12.9, 19.6) |
FHS indicates Framingham Heart Study; HDL, high-density lipoprotein; HGF, hepatocyte growth factor; eGFR, estimated glomerular filtration rate; SHIP, Study of Health in Pomerania. Data are mean±standard deviation; except for HGF, Angiopoietin-2, and soluble Tie-2 where median (quartile 1, quartile 3) are provided.
*
Genetic data were missing in 16 participants.
†
In ounces per month in FHS sample, in g/day in the SHIP-1 sample.