Table 2.
Genome-wide significant loci for circulating concentrations of hepatocyte growth factor (HGF), soluble Tie-2 (sTie-2) and Angiopoietin-2 (Ang-2); The most significant single nucleotide polymorphisms for each locus and biomarker are shown.
| Discovery sample, FHS Third Generation cohort |
Replication sample, SHIP-1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Biomarker | rsID | Chr | N | Coded/ Non-Coded Allele |
MAF | Beta (SE) | p-value | Closest Gene |
N | MAF | Beta (SE) | p-value |
| HGF | ||||||||||||
| rs5745687 | 7 | 3571 | T/C | 0.077 | −0.099 (0.011) |
3.64×10−19 | HGF | |||||
| Ang-2 | ||||||||||||
| rs8176746 | 9 | 3574 | T/G | 0.077 | 0.111 (0.020) |
2.07×10−8 | ABO | 3188 | 0.096 | 0.061 (0.019) |
0.001 | |
| rs2442517 | 8 | 3574 | G/A | 0.474 | 0.059 (0.011) |
5.05×10−8 | MCPH1 | 3188 | 0.461 | 0.043 (0.011) |
8.39×10−5 | |
| sTie-2 | ||||||||||||
| rs2273720 | 9 | 3574 | C/A | 0.056 | 0.265 (0.016) | 2.40×10−65 | Tie-2 | 3184 | 0.056 | 0.237 (0.018) | 2.70×10−38 | |
| rs8176693 | 9 | 3574 | T/C | 0.077 | 0.155 (0.013) | 1.84×10−33 | ABO | 3184 | 0.096 | 0.157 (0.014) | 2.53×10−30 | |
Chr. indicates chromosome; FHS, Framingham Heart Study; HGF, hepatocyte growth factor; Ang-2, Angiopoietin-2; MAF, minor allele frequency; SE, standard error; SHIP, Study of Health in Pomerania; SNP, single nucleotide polymorphism.