Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Circ Cardiovasc Genet. 2015 Jan 22;8(2):284–293. doi: 10.1161/CIRCGENETICS.113.000587

Figure 2.

Figure 2

Conduction defects in mature mice without the Gata6 carboxyl zinc-finger. (A, B) Surface ECG leads I, II, III. aVR, aVL & aVF along with intracardiac recordings of the right atrial electrogram (RAE) and His-bundle electrogram (HBE) from an adult Mlc2vCre-Gata6f/f (A) and Gata6f/f (B) mouse. Note the PR-interval is longer (red dashed lines) in the mutant mouse, with no gross defects in overall QRS-complex morphology or other intervals on the surface ECG leads. The Mlc2vCre-Gata6f/f mouse has a PR-interval of 57 ms vs. 46 ms for the Gata6f/f mouse. Recordings from the HBE show atriohisian (AH) interval prolongation (solid blue lines) without functional Gata6. The Mlc2v-CreGata6f/f mouse has an AH-interval of 42 ms vs. 31 ms for the Gata6f/f mouse. P=P-wave; QRS=QRS-complex; T=T-wave; a=atrial electrogram; v=ventricular electrogram.