Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 3;106(4):421–429. doi: 10.1111/cas.12610

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Fig 6 — Histopathology of xenografts in nude mice and illustration of potential mechanism by Myc-5. (a) Tissue sample were analyzed qualitatively for morphological changes. Magnification, ×10 (scale bar = 200 μm); magnification, ×40 (scale bar = 50 μm). (b, c) Quantitative data of immunohistochemical analysis of BrdU and TUNEL positive staining in each group. Data in (b, c) are shown as the mean ± SD of three tumor samples from an individual mouse in each group. Statistical significance was calculated by Student's t-test. ***P < 0.001. (d) Schematic diagram of the mechanism by which pyrrole–imidazole polyamide inhibits MYC/MAX interaction to the E-box. (I) MYC:MAX dimer binds to E-box and activates MYC target gene expression. (II) Myc-5 occupied the E-box by binding, thereby inhibiting the MYC/MAX interaction to the E-box, causing further suppression of target gene expression.