Figure 5.
A–F: Cardiomyocytes from remote non-infarct regions were isolated 1, 3, and 7 days post-MI. Cells were treated with gAPN or fAPN for 30 minutes. pAMPK/AMPK were determined. G–I: Cardiomyocytes from remote non-infarct regions of WT or cardiomyocyte-specific GRK2 deletion mice were isolated 7 days post-MI, and treated with APN in vitro. APN-induced AMPK phosphorylation and GLUT4 membrane translocation was determined. N=5 mice/group. *P<0.05, **P<0.01 vs. vehicle, $P<0.05, $$P<0.01 vs. sham.