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Scramble or GRK2 siRNA was administered via intramyocardial injection 2 days before MI. 7 days post-MI, animals were randomized to receive vehicle or gAPN (abdominal osmotic pump) for another 7 days. The GLUT4 translocation (A), AMPK phosphorylation (B), and cardiac function (LVEF) (C,D) were determined. N=11–14 animals/group. *P<0.05, **P<0.01 vs. sham; $P<0.05, $$P<0.01 vs. scramble group with the same treatment.
