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. Author manuscript; available in PMC: 2016 Apr 15.

Published in final edited form as: Int J Cardiol. 2015 Mar 5;185:198–208. doi: 10.1016/j.ijcard.2015.03.054

Table 1.

MMP-12 inhibition worsens LV geometry and function post-MI.

	Day 0	Day 7 MI Saline	Day 7 MI MMP-12i
Body Weight; g	30±1	28±1	26±1^*
LV Mass/ Body Weight; mg/g	3.0±0.1	4.0±0.2^*	4.0±0.2^*
RV Mass/Body Weight; mg/g	0.60±0.05	1.00±0.07^*	1.00±0.07^*
Wet Lung Weight/ Body Weight; mg/g	5.0±0.5	10±1^*	9±1^*
Infarct Wall Thickness (diastolic; mm)	0.90±0.03	0.66±0.04^*	0.56±0.04^*^#
LV Remodeling Index	0.84±0.08	1.50±0.15^*	1.91±0.15^*^#
LV Hypertrophy Index	4.0±0.1	10.0±0.8^*	13±1^*^#
End Diastolic Volume; μl	85±5	163±11^*	201±18^*^#
End Systolic Volume; μl	16±3	144±11^*	186±17^*^#
Ejection Fraction; %	81±3	13±1^*	8±1^*^#

Values are presented as mean±SEM, n=12/group.

^*

p<0.05 vs. day 0, and

^#

p<0.05 vs. saline treated mice.

Remodeling Index = End diastolic volume/LV mass. Hypertrophy index = End diastolic diameter/Average Systolic Wall Thickness. LV - Left ventricle; MI - Myocardial infarction.