View full-text article in PMC Genet Epidemiol. Author manuscript; available in PMC: 2016 May 1. Published in final edited form as: Genet Epidemiol. 2015 Apr 6;39(4):306–316. doi: 10.1002/gepi.21899 Search in PMC Search in PubMed View in NLM Catalog Add to search Copyright and License information PMC Copyright notice Table 2. A summary of the PRS test and its modifications without sample splitting. T is for a test statistic and P is for its p-value. Data D ={(Yi, Xi)|i = 1, …, n} = D1 υ D2 split to two parts D1 and D2. Model Logit [Pr(Yi = 1)] = βM,0 + XijβM,j, i ∈ D1. Output P-values pj(D1)’s for H0: βm,j = 0. Model Logit[Pr(Yi=1)]=β0+Σj=1kXijβj, Output U(D)=(U1(D),…,Uk(D))′=Σi∊DXi(Yi−Y‒),Y‒=Σi∊DYi∕∣D∣, U(Dm)=(U1(Dm),…,Uk(Dm))′=Σi∊DmXi(Yi−Y‒(m)),Y‒(m)=Σi∊Dm∕∣Dm∣form=1,2. Tests TPRS≈cΣj=1kUj(D1)Uj(D2)I(pj(D1)<PT)∕Var(Uj(D1)). TtSSUw(PT)=Σj=1kUj2(D)I(pj(D)<PT)∕Var(Uj(D)). TatSSUw(Ω)=minPT∊ΩPtSSUw(PT). TtSSU(PT)=Σj=1kUj2(D)I(pj(D)<PT). TatSSU(Ω)=minPT∊ΩPtSSU(PT). TSSU=Σj=1kUj2(D). TSPU(γ)=Σj=1kUjγ(D). TaSPU(Γ)=minγ∊ΓPSPU(γ). TtSPU(γ,PT)=Σj=1kUjγ(D)I(pj(D)<PT). TatSPU(Γ,Ω)=minγ∊Γ,PT∊ΩPtSPU(γ,PT).