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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Genet Epidemiol. 2015 Apr 6;39(4):306–316. doi: 10.1002/gepi.21899

Table 4.

Empirical Type I error rate (for a = 1) and power (for a > 1) for various tests. There are k1 = 100 causal SNPs with ORj ~ U(1, a) and all other k – k1 SNPs with ORj = 1. The highest power is in boldface.

k = 10000 SNPs k = 20000 SNPs

Test PT a = 1 1.15 1.2 1.25 1 1.2 1.25 1.3
PRS .001 0.038 0.068 0.135 0.315 0.057 0.083 0.196 0.532
.005 0.058 0.057 0.140 0.328 0.046 0.073 0.206 0.538
.01 0.055 0.058 0.127 0.352 0.053 0.097 0.203 0.497
.025 0.055 0.070 0.160 0.337 0.055 0.089 0.193 0.453
.05 0.051 0.075 0.149 0.338 0.050 0.099 0.186 0.434
.1 0.060 0.079 0.154 0.304 0.055 0.105 0.182 0.396

tSSU .001 0.063 0.154 0.436 0.841 0.057 0.288 0.685 0.958
.005 0.057 0.170 0.439 0.831 0.050 0.289 0.636 0.883
.01 0.052 0.181 0.442 0.781 0.046 0.292 0.569 0.833
.025 0.053 0.188 0.436 0.716 0.055 0.246 0.497 0.763
.05 0.059 0.189 0.409 0.670 0.063 0.241 0.465 0.690
.1 0.055 0.194 0.382 0.629 0.059 0.223 0.434 0.637

atSSU 0.065 0.229 0.515 0.880 0.061 0.334 0.686 0.940

SPU(1) 0.059 0.159 0.190 0.278 0.047 0.129 0.148 0.215
SPU(2) 0.049 0.181 0.377 0.637 0.053 0.240 0.418 0.626
SPU(3) 0.051 0.189 0.432 0.756 0.055 0.245 0.500 0.774
SPU(4) 0.059 0.245 0.581 0.880 0.058 0.361 0.714 0.939
SPU(5) 0.055 0.213 0.555 0.893 0.035 0.358 0.746 0.954
SPU(6) 0.054 0.244 0.600 0.911 0.047 0.417 0.819 0.980
SPU(oo) 0.053 0.122 0.305 0.628 0.063 0.234 0.533 0.853

aSPU 0.056 0.268 0.609 0.926 0.062 0.423 0.822 0.979