Table 4.
Multivariate regression results for morphine induced respiratory depression (MIRD) and pain outcomes
| Variable | Saturated model | Final model | ||
|---|---|---|---|---|
| Odds ratio (95% CI) | P-value | Odds ratio (95% CI) | P-value | |
| Results of regression for MIRD outcome | ||||
| Sex (female vs male) | 1.00 (0.55–1.88) | 0.98 | — | — |
| Race (Caucasian vs other) | 2.77 (1.15–12.08) | 0.061 | 6.24 (1.09–118.17) | 0.091 |
| Age (years) | 1.24 (0.91–1.72) | 0.19 | — | — |
| Morphine consumption/kga | 0.57 (0.26–1.14) | 0.13 | — | — |
| Use of basal infusion on PCA | 1.21 (0.62–2.54) | 0.59 | — | — |
| Diazepam dose/kga | 0.52 (0.01–15.96) | 0.71 | — | — |
| OPRM1 (AA vs AG+GG) | — | — | 5.57 (1.42–37.22) | 0.030 |
| Variable | Saturated Model | Final Model | ||
|---|---|---|---|---|
| Beta ± standard error | P-value | Beta ± standard error | P-value | |
| Results of regression with pain scores as outcome | ||||
| Sex (female vs male) | 0.11 ±0.21 | 0.59 | — | — |
| Race (Caucasian vs other) | − 0.25 ±0.24 | 0.31 | — | — |
| Age (years) | 0.07 ±0.11 | 0.51 | — | — |
| Morphine consumption/kga | 0.40 ±0.25 | 0.11 | — | — |
| Use of basal infusion on PCA | 0.02 ±0.23 | 0.92 | — | — |
| Diazepam (Y/N)a | − 0.35 ±0.23 | 0.13 | − 0.40 ±0.21 | 0.061 |
| Intraoperative Remifentanil/kg | − 0.25 ±0.45 | 0.57 | — | — |
| Surgical duration | − 0.001 ±0.003 | 0.65 | — | — |
| Intravenous Tylenol (Y/N)a | 0.07 ±0.20 | 0.73 | — | — |
| Intravenous Ketorolac (Y/N)a | − 0.08 ±0.18 | 0.65 | — | — |
| OPRM1 (AA vs AG+GG) | — | — | − 0.37 ±0.18 | 0.045 |
Abbreviations: CI, confidence interval; PCA, patient controlled analgesia.
a
Over postoperative days 1 and 2.