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. Author manuscript; available in PMC: 2016 May 4.
Published in final edited form as: Toxicology. 2015 Mar 14;331:66–77. doi: 10.1016/j.tox.2015.03.006

Figure 6. Structurally distinct environmental PPARγ ligands suppress osteogenesis in mouse BM-MSCs.

Figure 6

Primary bone marrow cultures were established from male C57BL/6J mice and treated with Vh (DMSO), TPhT (10–80 nM; A), MEHP (10–20 µM; B), METBP (10–20 µM; C), or TBBPA (10–20 µM; D), in the presence of osteoinductive media for 11 days. Osteogenesis was assessed by alkaline phosphatase activity, alizarin staining and bone nodule counting. Data are presented as means ± SE (n = 5–8 independent bone marrow preparations). *p < 0.05, **p < 0.01 compared to Vh-treated cultures (ANOVA, Dunnett’s).