Fig. 6.
Inhibition of HIF-1α regulates gene transcription of Cav1.2 and Cav1.3 detected by luciferase reporter assays. The binding of HIF-1α to Cav1.2 and Cav1.3 gene promoters was augmented in 3 % O2 compared with that in 20 % O2. After echinomycin treatment, binding of HIF-1α to the Cav1.2 gene promoter (a) was attenuated, while there was an enhancement of the binding of HIF-1α to the Cav1.3gene promoter (b). **P < 0.01 vs 20 % O2; # P < 0.05 vs 20 or 3 % O2; ## P < 0.01 vs 20 or 3 % O2; ### P < 0.001 vs 20 or 3 % O2; “n” stands for the number of independent experiments