Fig. 2.

On a HFD, Hsp72 Tg mice maintain whole body insulin responsiveness and skeletal muscle glucose clearance but not cardiac glucose clearance. Mice were fed a normal chow (NC) or high-fat diet (HFD) for 12 weeks from 8 weeks of age. a Blood glucose response following an intravenous injection of insulin and b average blood glucose concentration over the 35-min period post insulin/tracer injection. c Cardiac glucose clearance rate, d skeletal muscle glucose clearance (quadriceps), e skeletal muscle glucose clearance (gastrocnemius), and f white adipose tissue (epididymal fat pad) glucose clearance, n = 6–8 per group. *p < 0.05, **p < 0.01, ***p < 0.001 for dietary effect; ^† p < 0.05, ^†† p < 0.01 for genotype effect; ^## p < 0.01 for a direct comparison between WT HFD and Hsp72 Tg HFD groups by a t test. All data are presented as mean ± SEM