Fig. 5.

PNEC estimates grouped according to therapeutic classes as defined by the Anatomical Therapeutic Chemical (ATC) Classification System. PNEC estimates have been color coded according to the data input ultimately used in the derivation of ADIs following the procedure of Figure 1 as follows: ADI_vet (), LOTD (), LTD₁₀ (), NSRL (), OEL (), TDI (). *Classifications according to the World Health Organization ATC classification system (47) where abbreviations used on the y-axis represent the following classes of drugs: A alimentary tract and metabolism; B blood and blood forming organs; C cardiovascular system; D dermatologicals, G genito-urinary system and sex hormones; H systemic hormonal preparations; J antiinfectives; L antineoplastic and immunomodulating agents; M musculo-skeletal system; N nervous system; P antiparasitic products; R respiratory system; S sensory organs; V various