Fig. 6.

Margin of exposure, MOE_p3 (PNEC_dw divided by PEC₃), estimates grouped according to therapeutic classes as defined by the Anatomical Therapeutic Chemical (ATC) Classification System. MOE_p3 estimates have been color coded with respect to their estimated risk to human health as follows: Possible risk (); Low risk, but should be considered for further prioritization (); Negligible risk (). *Classifications according to the World Health Organization ATC classification system (47) where abbreviations used on the y-axis represent the following classes of drugs: A alimentary tract and metabolism; B blood and blood forming organs; C cardiovascular system; D dermatologicals, G genito-urinary system and sex hormones; H systemic hormonal preparations; J antiinfectives; L antineoplastic and immunomodulating agents; M musculo-skeletal system; N nervous system; P antiparasitic products; R respiratory system; S sensory organs; V various