Fig. 2.

PK model of remoxipride delivered through IN administration. Compartment numbers are shown between brackets. Two absorption compartments exist, which describe absorption of drug into the central compartment (systemic circulation) and another one which describes direct drug absorption into the brain (direct nose-to-brain transport). The central compartment represents the remoxipride concentrations in plasma. Distribution of drug into other tissues and organs is described by the peripheral compartment. Lastly, the brain compartment represents drug concentrations in the ECF (34). Parameter values are provided in Table III