Table 2.
General statistics on ANDCell database content and descriptions of molecular-genetics interactions.
| Interaction type | Involved objects | Description | Number of ANDCell entries |
|---|---|---|---|
| association | Proteins, genes, metabolites, cell components, diseases, pathways | Association type is used to define the relationships between genes and diseases. The Association is also used as a type of relationship between other objects, if a particular type of relationship has been omitted in the text. | 3,433,168 |
| involvement | Proteins, pathways | Involvement of proteins into pathways (UniProt-GOA). | 728,947 |
| interaction | Proteins, genes, metabolites, cell components | Formation of molecular complexes. | 242,757 |
| expression | Proteins, genes | The protein product of gene expression (NCBI gene) | 178,761 |
| expression regulation* | Proteins, genes | Direct regulation by a transcription factor that physically interacts with a gene promoter and indirect regulation of gene expression by proteins. | 236,298 |
| pathway regulation* | Proteins, metabolites, pathways | Activation and termination of pathway functioning. | 234,179 |
| transport regulation | Proteins, metabolites | Regulation of transport proteins or metabolites between cell compartments, as well as the secretion of these molecules from the cell. | 64,810 |
| treatment | Proteins, metabolites, diseases | The use of a molecular agent for treatment of a known disease. | 51,195 |
| catalyze | Proteins, metabolites | Catalytic reactions are reactions involving metabolites as substrates and products; also, a protein as an enzyme catalyzing this reaction. | 49,173 |
| activity regulation* | Proteins, metabolites, cellular components | Regulation of activity/function of proteins and cellular components. | 101,953 |
| degradation regulation* | Proteins, metabolites, cellular components | Regulation of stability or degradation of molecular objects. | 17,751 |
| miRNA regulation | miRNA, proteins | Regulation of protein expression. | 23,576 |
| coexpression | Genes | Co-expression of several genes. | 6,618 |
| cleavage | Proteins | Protein cleavage events. Protein substrate and proteolytic enzyme are participants. | 2,178 |
| catalyzed modification | Proteins, metabolites | Catalysis of post-translational protein modifications. | 430 |
| conversion | metabolites | Catalytic reaction in a case when a catalyst enzyme is not indicated; also when the reaction proceeds without a catalyst. | 23,519 |
* three types of regulations (regulation, upregulation and downregulation) are presented for this group.