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. 2015 Feb 27;138(5):1223–1238. doi: 10.1093/brain/awv046

Figure 6.

Figure 6

Comparison of myelin imaging biomarkers as defined by DBSI, DTI and MTR. MTR (A) and FLAIR (B) images were used to guide the selection of 42 regions of interest with a wide range of MTR contrast in three multiple sclerosis patients. One region of interest adjacent to the posterior lateral ventricle (MTR = 0.04) and one region of interest are noted by white arrow heads in the normal-appearing corpus callosum (MTR ≈ 0.4). Reduced MTR correlated with increased DBSI radial diffusivity (B, E and H) and DTI radial diffusivity (C, F and I), in accordance with the idea that each of these three imaging biomarkers represents myelin integrity. MTR also correlated with DBSI non-restricted isotropic fraction (D, G and J), suggesting that MTR is also sensitive to increased water content, likely oedema and/or tissue loss. The red circle, yellow triangle, and blue squares indicated the data from Patients 1, 2 and 3, respectively.