Table 2.
Adjusted odds ratios (95% CI) for hs-CRP ≥ 3 mg/L at follow-up (2007–10) by baseline (1967–73) risk factor status and single baseline risk factors — the Chicago Healthy Aging Study.
| N | OR (95% CI) |
||
|---|---|---|---|
| Model 1a | Model 2a | ||
| Baseline RF statusb | |||
| LR | 259 | 1.00 | 1.00 |
| 0 RF | 423 | 1.25 (0.83–1.87) | 1.35 (0.89–2.03) |
| 1 only RF | 449 | 1.56 (1.05–2.31) | 1.61 (1.08–2.40) |
| ≥ 2 RFs | 193 | 1.55 (0.96–2.50) | 1.69 (1.04–2.75) |
| β coefficient/P trendc | 0.16 (0.023) | 0.18 (0.014) | |
| Single baseline risk factors | |||
| Smoking status | |||
| Never smoker (ref.) | 608 | 1.00 | 1.00 |
| Former smoker | 397 | 1.14 (0.82–1.59) | 1.14 (0.82–1.59) |
| Current smoker | 319 | 1.75 (1.26–2.43) | 1.69 (1.21–2.36) |
| SBP/DBP, mm Hg | 612 | 1.00 | 1.00 |
| ≤ 120/≤ 80, no med. (ref.) | 339 | 1.17 (0.84–1.63) | 1.21 (0.87–1.70) |
| 121–139, no med. ≥ 140/90 or on med. | 373 | 0.73 (0.51–1.05) | 0.75 (0.52–1.08) |
| Serum total chol., mg/dL | |||
| < 200, no med. (ref.) | 892 | 1.00 | 1.00 |
| 200–239, no med. | 339 | 0.81 (0.59–1.13) | 0.90 (0.64–1.27) |
| ≥ 240 or on med. | 93 | 1.27 (0.76–2.12) | 1.46 (0.85–2.49) |
| BMI (kg/m2) | |||
| < 25 (ref.) | 685 | 1.00 | 1.00 |
| 25–29 | 556 | 1.29 (0.95–1.75) | 1.33 (0.97–1.82) |
| ≥ 30.0 | 83 | 2.03 (1.18–3.49) | 2.00 (1.16–3.46) |
| Diabetes | 9 | 0.34 (0.04–2.86) | 0.35 (0.04–2.93) |
Abbreviations: see Table 1 footnotes.
The bold-faced indicates OR (95%CI) significance level of < 0.05. The Italic and bold-faced indicate the significant results for the trend test across4 baseline RF groups.
a
Model 1: Adjusted for baseline age, sex, and race; Model 2: Adjusted for variables in Model 1 plus education attainment, and current cancer, taking aspirin, taking lipid-lowering medication, and presence of ECG major abnormalities/CVD.
b
Definition of baseline RF status: see Table 1 footnotes.
c
P value for trend across 4 baseline RF groups.