Table 2.
Outcome variables over time (by group)
| Measure | Placebo | Galantamine | p-value for effect | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline (n = 18) |
Week 12 (n = 16) |
Week 24 (n = 13) |
Baseline (n = 19) |
Week 12 (n = 9) |
Week 12 (n = 9) |
group effect |
time effect |
group *time effect |
|
| HDRS-24 | 30.3 (6.7) | 12.3 (7.3) | 11.9 (6.9) | 26.4 (4.5) | 11.0 (6.9) | 6.1 (3.2) | 0.187 | <0.0001 | 0.575 |
| RBANS | |||||||||
| IM | 86.7 (16.2) | 97.9 (12.8) | 106.2 (10.8) | 90.6 (15.6) | 101.4 (11.0) | 103.1 (9.2) | 0.775 | 0.0002 | 0.453 |
| VIS | 83.7 (18.2) | 97.1 (17.2) | 98.8 (13.5) | 87.0 (19.6) | 97.1 (21.6) | 87.6 (18.5) | 0.966 | 0.019 | 0.219 |
| Language | 87.9 (13.1) | 94.6 (4.7) | 96.4 (6.8) | 95.1 (10.0) | 97.4 (7.0) | 96.0 (7.5) | 0.020 | 0.011 | 0.159 |
| Attention | 84.6 (20.5) | 95.3 (13.5) | 96.6 (15.5) | 94.3 (18.2) | 94.1 (17.8) | 94.3 (16.1) | 0.620 | 0.033 | 0.167 |
| DLmem | 86.7 (14.2) | 99.6 (13.8) | 107.5 (13.9) | 98.7 (10.4) | 104.4 (12.7) | 107.0 (12.2) | 0.028 | <0.0001 | 0.090 |
| Tsotal | 81.6 (14.6) | 95.3 (10.9) | 101.2 (12.9) | 90.9 (16.5) | 98.9 (15.3) | 96.3 (13.1) | 0.226 | 0.0001 | 0.084 |
Dlmem = Delayed Memory; HDRS-24 = 24-item Hamilton Depression Rating Scale; IM = Immediate Memory; RBANS = Repeatable Battery for Neuropsychological Status; VIS = Visuospatial/Construction.