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. 2014 Dec 20;16:504. doi: 10.1186/s13058-014-0504-9

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© Verbeke et al.; licensee BioMed Central 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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EGFR family gene expression in normal and tumor cells. A. Illumina gene expression data from normal human reduction mammoplasty cells (mean + SEM). MaSC, mammary stem cell; LP, luminal progenitor; ML, mature luminal. Error bars sem; † p < 0.01; * p < 0.05; n = 3; the p values are for comparisons of ML with the other groups. B&C. Affymetrix gene expression data for large operable or locally advanced breast cancer. The scatterplot in B shows how the tumors were classified into luminal (ER+/FOXA1+, 43 samples); molecular apocrine (ER-/FOXA1+, 49 samples); and basal-like (ER-/FOXA1-, 69 samples). The plots in C show the expression profile of EGFR family members in each tumor class. The distributions are strikingly bimodal (see text for details). The maximum density for each distribution is scaled to 1 to facilitate comparison of the different tumor classes.