Table 2.
Binding energy of selected substrates for Ws SGTL1 and Ws SGTL4 proteins
| Ligands | Binding energy (kcal/mol) | |
|---|---|---|
| Sterols | Ws SGTL1 | Ws SGTL4 |
| β-Sitosterol | −9.44 | −8.36 |
| Brassicasterol | −11.36 | −7.97 |
| Deactyl-16-DPA | −8.54 | −8.0 |
| Dehydroepiandrosteron | −8.28 | −7.57 |
| Epoxypregnenolone | −7.14 | −6.25 |
| Ergosterol | −9.71 | −8.21 |
| Pregnenolone | −8.97 | −7.88 |
| Solasodine | −9.42 | −9.4 |
| Stigmasterol | −9.42 | −9.4 |
| Transandrosterone | −9.95 | −8.44 |
| 24-methylene cholesterol | −9.75 | −8.65 |
| Withanolides | ||
| Withaferin A | −10.21 | −9.14 |
| Withanolide A | −9.28 | −10.51 |
| Withanolide B | −9.19 | −9.21 |
| Withanolide D | −9.28 | −8.96 |