Table 5.
Highly polymorphic loci in Cryptosporidium hominis genomes
| Locus | Contig in 30976 | SNP/kb (30976 vs Tu502) | Gene in C. hominis* | Ortholog in C. parvum* | Annotation |
|---|---|---|---|---|---|
| chr1_var1 | contig_5 | 5.0 | Chro.10024 | cgd1_150 | Hypothetical protein with a signal peptide |
| chr1_var2 | contig_5 | 9.0 | Chro.10427 | cgd1_3810 | Conserved hypothetical protein with a signal peptide |
| chr2_var1 | contig_32 | 9.5 | Chro.20050-52 | cgd2_430-450 | Mucin glycoprotein with a signal peptide |
| chr2_var2 | contig_20 | 5.0 | Intergenic downstream of Chro.20394 | Intergenic downstream of cgd2_3690 | WD repeat protein (cgd2_3690) |
| chr3_var1 | contig_59 | 5.0 | Intergenic downstream of Chro.30096 | Within cgd3_720 | Very large mucin with a signal peptide |
| chr3_var2 | contig_31 | 6.5 | Chro.30315 | cgd3_2770 | Hypothetical conserved protein |
| chr3_var3 | contig_293 + contig_255 | 7.0 | Chro.30479 | cgd3_4260 | Insulinase-like protease |
| chr6_var1 | contig_3 | 9.0 | Chro.60606 | cgd6_5270 | Hypothetical protein with a signal peptide |
| chr8_var1 | contig_11 | 5.5 | Chro.80070 | cgd8_550 | Large uncharacterized protein |
| chr8_var2 | contig_2 | 6.0 | Chro.80189 | cgd8_1610 | Sacsin-like HSP90 chaperone domain |
*Additional polymorphic genes identified by comparative analysis of other isolates with C. hominis TU502: Chro.60016 (ortholog of cgd6_60), and Chro.60138 (ortholog of cgd6_1080).