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. 2015 Apr 22;5:19. doi: 10.1186/s13578-015-0010-5

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© Visagie et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of EMBS on Bcl-2 expression and pBcl-2(s70) phosphorylation. Flow cytometry investigation of Bcl-2 expression (FL1 Log) and pBcl-2(s70) phosphorylation (FL3 Log) of vehicle-treated MCF-7 (A), MDA-MB-231 (B) and MCF-12A cells (C). Treated cells were exposed to 0.4 μM for 24 h and demonstrated a downregulated protein expression of Bcl-2 and pBcle-2(s70) phosphorylation status in MCF-7 (D), MDA-MB-231 (E) and MCF-12A cells (F). Actinomycin D-treated cells were used as a positive control for apoptosis and showed a decrease in Bcl-2 protein expression and Bcl-2(s70) phosphorylation status in MCF-7 (G), MDA-MB-231 (H) and MCF-12A cells (I).